The Trilogy: Genetics, Leaky Gut, and Gluten


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The Trilogy:  Genetics, Leaky Gut (Hyper Intestinal Permeability), and Gluten –>  Recipe for an Auto Immune Disease


When traveling out of town this weekend, I was inquiring about ingredients in a hollandaise sauce.  Our waiter wasn’t sure so he sent out the chef, who literally said “I can’t say it’s gluten free but do I think it’ll bother you?  No.  Unless you are full blown Celiac, I think you’ll be fine”.

These words, from a well meaning but incredibly uninformed chef, sparked todays video blog.

YOU have to be your own advocate in terms of what is safe for you to eat and what isn’t.

Let me explain HOW important this is!

1 in 2 now have some form of an auto immune disease.  Why don’t you hear about it?  Because we classify them as Rheumatoid Arthritis, MS, Hashimoto’s, Celiac, Type 1 Diabetes, Hashimoto’s, Auto Immune Hepatitis, Ankylosing Spondylitis, etc.

AND, diseases like asthma and heart disease are now found to have an auto immune component.  So it’s easy to see how 1 in 2 can be affected.

So in my opinion, we’re ALL at risk of some auto immune disease.  We all have genes and if you follow me and think you are “just” gluten sensitive because you don’t have DQ2 or DQ8 (so you cant have celiac disease)….how do you know you don’t have HLA B27 and aren’t at risk of Hashimoto’s?  Or the genes that are implicated for Type 1 Diabetes.   Get it?   We all are going to have genes that predispose us to something!

The “Trilogy” perfect storm to initiate an auto immune disease is
1.  Genetics.  For example, the genes HLA DQ2 and DQ8 predispose one to Celiac disease.

2.  A Leaky Gut – Intestinal Hyper Permeability.  And LOTS of things cause a leaky gut:  alcohol, NSAID’s, GMO’s, Pesticides, Herbicides, Insecticides, SIBO (Small Intestine Bacterial Overgrowth), Medications, & Stress.  Get it?  We’re all at risk somehow.

3.  Now a trigger comes a long and gluten is a likely trigger.  It’s not the same gluten it was in your grandma’s time.  We’ve changed it so much, increased the protein that it is not digestible.

So to summarize, it’s important to stand up for yourself in restaurants, at your in-laws etc….because we’re probably all at risk of some auto immune disease.  If you know you are sensitive to it, DON’T EAT IT.  Eating gluten if you are sensitive can cause leaky gut.  And then the gluten is the trigger too as it crosses the mucosal barrier and our immune system attacks.

If you do have a leaky gut – for whatever reason – you can or have opened up the door to your own auto immune disease.

Auto immune diseases take time.  An average of 9 years before you have enough tissue damage and antibodies that you now get the “jersey” and the ICD-9 code (and the drug!)

Eat and Be Well.
With love hope and encouragement,


Comments?  Tell me HERE.

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 About Tracy Konoske, MS, RDN

meet_tracyTracy Konoske is an eclectic clinician and uses a blend of natural, integrative, functional, and personalized medicine to help her patients feel their best.  Tracy understands that there are 4 drivers of chronic disease:  Toxins, Infections, Stress, and Diet.  And it's often a combination of all 4 that lead to a chronic health condition, and thus it takes a treatment plan addressing each of the 4 to resolve and reclaim good health.  Tracy has recovered from 2 "perfect storm" situations which had drastic effects on her health and led to multiple mystery illnesses and diagnosis including Lyme.

By reducing the burden of these triggers, Tracy is successfully resolving:

  • Fatigue (anemia's, adrenals, thyroid-related, chronic fatigue syndrome, ME-CFS)
  • Auto Immune Conditions (Hashimoto's, Lupus, MS, Rheumatoid Arthritis, Celiac)
  • Mental Health Conditions (anxiety, depression, OCD, ADD/ADHD)
  • Cognitive Dysfunction (trouble concentrating, forgetfulness, symptoms of early Alzheimer's)
  • Digestive Disorders (low hydrochloric acid, "leaky gut", Candida Albicans, Small Intestine Bacterial Overgrowth SIBO, IBS, Crohn's Disease, Ulcerative Colitis)
  • Migraines and chronic headaches
If you've one or more of the above-mentioned conditions, or have been told you have Lyme or chronic Lyme,  there's a good chance you are in the right place.If you have a history of chronic sore throats, tonsillitis or tonsillectomy, mononucleosis, glandular fever, shingles, and/or cold sores, there's a good chance you are in the right place.

There are no coincidences.  All good things come from God.